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Best over counter medications - November 2025

Last Updated - November 7, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

$22.79

More Details
Main highlights
- Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
- Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
- One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
- Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
- Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
- HSA and FSA eligible product
- Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
$22.79
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Vicks

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Vicks

$19.97

More Details
Main highlights
- WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.
- RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
- PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
- POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
- NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
$19.97
3
24% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
- Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
- Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
- Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
- Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach
$12.47
$16.59 (24% Off)
4
Best Value
37% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Imodium
37% Off

Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

Imodium

$13.54

$21.81
(37% Off)

More Details
Main highlights
- Travel essential: convenient tear-away blister packs provide compact, portable softgel packs for road trip essentials and everyday carry; trusted diarrhea medication for adults and older kids 12+ fits easily in purse, backpack or carry-on bag
- Restores natural balance: nonstimulant formula works with your body to restore digestive rhythm by gently slowing gut activity; supports nutrient absorption and minimizes cramps and urgency for comfortable, reliable relief
- Fast-acting relief: softgels with loperamide HCl 2 mg work in as little as one hour to control diarrhea symptoms; clinically proven anti-diarrheal formula slows intestinal movement faster than bismuth subsalicylate for rapid, reliable symptom control
- Doctor-recommended brand: Imodium A-D offers trusted symptom control for acute and Traveler’s diarrhea; these anti diarrhea pills are formulated with loperamide HCl 2 mg for gentle yet effective relief
- Clear dosing instructions: each softgel contains 2 mg loperamide hydrochloride; take two after the first loose stool and one after each subsequent stool, up to four in 24 hours; HSA/FSA eligible anti-diarrheal medicine
$13.54
$21.81 (37% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

Amazon Basic Care

$9.53

More Details
Main highlights
- TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
- Product may be manufactured in India or Israel
- HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
- ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
- ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
- 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
$9.53

Best over counter medications - November 2025

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

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Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Motrin IB Ibuprofen 200mg Tablets, Fast-Acting Pain Reliever & Fever Reducer, Over-the-Counter Cold Medicine for Headache, Backache, Toothache, Menstrual Cramps & Minor Arthritis Pain, 225 Count

Ricola Max Honey Lemon Throat Care Large Bag | Cough Suppressant Drops | Dual Action Liquid Center | Soothing Long-Lasting Relief - 34 Count (Pack of 1)

Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

Pepto Bismol Pepto-Bismol Chewable Tablets, 30 ct,

Ricola Sugar Free Lemon Mint Throat Drops, 45 Count, Refreshing Relief From Minor Throat Irritations, Oral Anesthetic

Amazon Basic Care Stool Softener Laxative, Docusate Sodium 100 mg, Softgels, For Constipation Relief, 100 Count

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