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Best acetaminophens - November 2025

Last Updated - November 7, 2025

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Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care

$21.30

More Details
Main highlights
- TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
- PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
- PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
- ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
- ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
$21.30
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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

Amazon Basic Care

$19.65

More Details
Main highlights
- GLUTEN FREE: This pain reliever and fever reducer is free of gluten, aspirin and caffeine.
- FOR ADULTS: Amazon Basic Care Rapid Release Pain Relief, Acetaminophen Caplets 500 mg contain an extra strength pain reliever and fever reducer for adults and children ages 12 years and over
- EXTRA STRENGTH: These extra strength caplets are made for fast relief, with 500 mg of acetaminophen; package features a child-resistant cap
- EFFECTIVE: This product temporarily relieves minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache and premenstrual and menstrual cramps. Also temporarily reduces fever.
- ACTIVE INGREDIENT: Amazon Basic Care Rapid Release Acetaminophen 500 mg Caplets active ingredient is 500 mg of acetaminophen, a pain reliever and fever reducer. Compare to Tylenol Extra Strength Rapid Release Gels active ingredient.
$19.65
3
Best Value

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

TIME-CAP LABS, INC.

Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

TIME-CAP LABS, INC.

$9.35

More Details
Main highlights
- Relieve Minor Aches and Pains ... Toothache? Backache? Acetaminophen relieves minor aches and pains due to headache, backache, toothache, the common cold, minor pain of arthritis, muscular aches, and premenstrual and menstrual cramps.
- One in Every Medicine Cabinet ... Make sure every medicine cabinet and first-aid kit has these great headache relief tablets. 500 tablets are plenty enough to provide relief for the family.
- Let That Fever Subside ... Dealing with a fever? Acetaminophen temporarily reduces fever, and relieves those aches and pains caused by minor pain of arthritis.
- Highest Quality ... These OTC medications & treatments provide the same efficacy as your usual branded extra strength acetaminophen.
- An Easy Way to Be Pain-Free … Find fast-acting pain relief in a bottle of this Extra Strength Acetaminophen 500mg. Take as directed on the bottle.
$9.35
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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

GoodSense

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

GoodSense

$11.81

More Details
Main highlights
- USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
- PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
- GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. It also temporarily reduces fever
- ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
- ACTIVE INGREDIENT: GoodSense Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol Caplets
$11.81
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

HealthA2Z

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z

$12.99

More Details
Main highlights
- ✅ Trusted Everyday Relief: Safe and effective when used as directed for adults and children 12 years and older.
- ✅ Reduces Fever: Helps temporarily reduce fever and provide comfort during colds or flu.
- ✅ Gentle on Stomach: Contains no aspirin, caffeine, or ibuprofen — suitable for those with sensitive stomachs.
- ✅ Fast, Effective Pain Relief: Each caplet contains 500 mg of acetaminophen to relieve headaches, backaches, muscle aches, toothaches, and menstrual pain.
$12.99

Best acetaminophens - November 2025

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

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RIGHT REMEDIES Extra Strength Pain Relief, Acetaminophen 500 mg Caplets, Pain Reliever & Fever Reducer, Value Pack (300 Count)

Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary

Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct

TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

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